08-28-2023, 06:34 AM
Maraviroc is an immune modulator. It cures Long Covid by suppressing CCR5 activity, which is out of whack. It appears that suppressing CCR5 activity also helps treat Alzheimers.
Inexpensive pill used to treat HIV could cure Alzheimer’s, researchers reveal
CAMBRIDGE, United Kingdom — An inexpensive pill for treating HIV could potentially cure Alzheimer’s, according to new research. The drug maraviroc, marketed under the brand name Selzentry, clears rogue proteins in the brain, thereby preventing dangerous buildup and slowing the progression of the disease. The results are encouraging, since the U.S. Food and Drug Administration approved maraviroc for use in 2007. Researchers now hope that repurposing the medication could reverse memory loss in older people.
“We’re very excited about these findings because we’ve not only discovered a new mechanism of how our microglia hasten neurodegeneration, but we’ve also shown that this process can be interrupted, potentially even with an existing, safe treatment,” says senior author Professor David Rubinsztein from the UK Dementia Research Institute at Cambridge University.
Microglia, the specialist immune cells in the brain and central nervous system, are responsible for protecting against unwanted and toxic materials. In dementia, they become activated, but in a way that impairs the process of autophagy, through which cells degrade and recycle their components.
In lab rodents, the researchers demonstrated that during neurodegeneration, microglia release a suite of molecules that trigger a genetic switch called CCR5. This leads to the accumulation of a chemical called tau in clumps, ultimately destroying brain cells.
The team tested mice genetically altered to develop forms of dementia characterized by tau buildup. When they knocked out CCR5 activity, the animals were protected, unlike the controls. The CCR5 gene is also used by HIV as a “doorway” into our cells and is inhibited by maraviroc, which prevents the virus from replicating.
Approximately 90 percent of patients have the strain that the drug can suppress. The researchers administered the drug to the mice for four weeks, starting when the mice were two months-old. Upon examining their brains, they observed a significant reduction in the number of toxic proteins compared to untreated peers.
The same effect was observed in mice with dementia and Huntington’s disease, a cognitive disorder that can lead to dementia. The drug not only reduced tau aggregates compared to untreated mice but also slowed down the loss of brain cells. Treated mice performed better in an object recognition test, suggesting that the drug slowed down memory loss, as reported in the journal Neuron.
studyfinds.org
Bruce Patterson's company is IncellDX. Here is the website:
covidlonghaulers.com
Around 80% of his Long Covid patients recover.
Cort Johnson has written some informative articles on Patterson. Johnson is excessively critical of Patterson, but Johnson does understand the science well and does a good job researching and explaining it.
healthrising.org
healthrising.org
healthrising.org
.....
Can the music of Queen help diabetics produce insulin? Science says yes - study
Scientists have found a method to stimulate the body's cells to release insulin within minutes using music, and it works especially well with "We Will Rock You" by Queen.
By JUDY SIEGEL-ITZKOVICH
Published: AUGUST 23, 2023 14:04
Updated: AUGUST 23, 2023 14:55
An artistic illustration of rock music.
(photo credit: INGIMAGE)
It sounds like just another piece of fake news from social media, but in fact it has just been published by Swiss researchers in the prestigious British medical journal The Lancet.
To produce and administer insulin implanted in the body of diabetics instead of via insulin injections, Prof. Martin Fussenegger from the biosystems science and engineering department at ETH Zurich in Basel and colleagues are working to enclose insulin-producing designer cells in capsules that can be implanted in the body. To be able to control from the outside when and how much insulin the cells release into the blood, researchers have studied and applied different triggers in recent years –light, temperature, and electric fields.
They have now developed another novel stimulation method using music to trigger the cells to release insulin within minutes. Fussenegger says this works especially well with “ We Will Rock You,” a global hit by British rock band, Queen.
We are the champions: How Queen can help the body produce insulinThe clinical application, however, is still a long way off. The researchers have just provided a proof of concept, showing that genetic networks can be controlled by mechanical stimuli such as sound waves. Whether this principle will ever be put to practical use depends on whether a pharmaceutical company is interested in doing so. It could, after all, be applied broadly – the system works not only with insulin, but with any protein that lends itself to therapeutic use.
In diabetes, the body produces too little or no insulin. Diabetics thus depend on an external supply of this hormone via regular injections or an insulin pump attached to the body. Researchers led by want to make the lives of these people easier and are looking for solutions.
Inexpensive pill used to treat HIV could cure Alzheimer’s, researchers reveal
CAMBRIDGE, United Kingdom — An inexpensive pill for treating HIV could potentially cure Alzheimer’s, according to new research. The drug maraviroc, marketed under the brand name Selzentry, clears rogue proteins in the brain, thereby preventing dangerous buildup and slowing the progression of the disease. The results are encouraging, since the U.S. Food and Drug Administration approved maraviroc for use in 2007. Researchers now hope that repurposing the medication could reverse memory loss in older people.
“We’re very excited about these findings because we’ve not only discovered a new mechanism of how our microglia hasten neurodegeneration, but we’ve also shown that this process can be interrupted, potentially even with an existing, safe treatment,” says senior author Professor David Rubinsztein from the UK Dementia Research Institute at Cambridge University.
Microglia, the specialist immune cells in the brain and central nervous system, are responsible for protecting against unwanted and toxic materials. In dementia, they become activated, but in a way that impairs the process of autophagy, through which cells degrade and recycle their components.
In lab rodents, the researchers demonstrated that during neurodegeneration, microglia release a suite of molecules that trigger a genetic switch called CCR5. This leads to the accumulation of a chemical called tau in clumps, ultimately destroying brain cells.
The team tested mice genetically altered to develop forms of dementia characterized by tau buildup. When they knocked out CCR5 activity, the animals were protected, unlike the controls. The CCR5 gene is also used by HIV as a “doorway” into our cells and is inhibited by maraviroc, which prevents the virus from replicating.
Approximately 90 percent of patients have the strain that the drug can suppress. The researchers administered the drug to the mice for four weeks, starting when the mice were two months-old. Upon examining their brains, they observed a significant reduction in the number of toxic proteins compared to untreated peers.
The same effect was observed in mice with dementia and Huntington’s disease, a cognitive disorder that can lead to dementia. The drug not only reduced tau aggregates compared to untreated mice but also slowed down the loss of brain cells. Treated mice performed better in an object recognition test, suggesting that the drug slowed down memory loss, as reported in the journal Neuron.
studyfinds.org
Bruce Patterson's company is IncellDX. Here is the website:
covidlonghaulers.com
Around 80% of his Long Covid patients recover.
Cort Johnson has written some informative articles on Patterson. Johnson is excessively critical of Patterson, but Johnson does understand the science well and does a good job researching and explaining it.
healthrising.org
healthrising.org
healthrising.org
.....
Can the music of Queen help diabetics produce insulin? Science says yes - study
Scientists have found a method to stimulate the body's cells to release insulin within minutes using music, and it works especially well with "We Will Rock You" by Queen.
By JUDY SIEGEL-ITZKOVICH
Published: AUGUST 23, 2023 14:04
Updated: AUGUST 23, 2023 14:55
An artistic illustration of rock music.
(photo credit: INGIMAGE)
It sounds like just another piece of fake news from social media, but in fact it has just been published by Swiss researchers in the prestigious British medical journal The Lancet.
To produce and administer insulin implanted in the body of diabetics instead of via insulin injections, Prof. Martin Fussenegger from the biosystems science and engineering department at ETH Zurich in Basel and colleagues are working to enclose insulin-producing designer cells in capsules that can be implanted in the body. To be able to control from the outside when and how much insulin the cells release into the blood, researchers have studied and applied different triggers in recent years –light, temperature, and electric fields.
They have now developed another novel stimulation method using music to trigger the cells to release insulin within minutes. Fussenegger says this works especially well with “ We Will Rock You,” a global hit by British rock band, Queen.
We are the champions: How Queen can help the body produce insulinThe clinical application, however, is still a long way off. The researchers have just provided a proof of concept, showing that genetic networks can be controlled by mechanical stimuli such as sound waves. Whether this principle will ever be put to practical use depends on whether a pharmaceutical company is interested in doing so. It could, after all, be applied broadly – the system works not only with insulin, but with any protein that lends itself to therapeutic use.
In diabetes, the body produces too little or no insulin. Diabetics thus depend on an external supply of this hormone via regular injections or an insulin pump attached to the body. Researchers led by want to make the lives of these people easier and are looking for solutions.